Professor of Surgical Oncology and Honorary Consultant Urological Surgeon

Email: gds35@cam.ac.uk

Biography/Research interests

As Professor Surgical Oncology, Professor Stewart aims to leverage the strengths of academic surgical oncology (clinical surgery, trials and biosampling/translational research) to enhance the cure rate following surgical treatment of cancer. He has a specific interest in optimising management of patients with initially localised renal cancer, an area of great need within the disease.

Clinically, Professor Stewart undertakes a full range of treatments for renal cancer at Addenbrooke’s Hospital, from robotic partial nephrectomy for small renal cancers to multi-speciality surgery for locally advanced disease. In order to make practice changing developments in this area, Professor Stewart has developed a range of interlinked clinical trials and translational research, which are all underpinned by clinical excellence in managing renal cancer at Addenbrooke’s Hospital, Cambridge. To deliver on the above goals, he coordinates the Cambridge Renal Cancer Collaboration (CamRenCan) a group of over 40 clinicians, translational researchers and basic scientists across the Cambridge Biomedical Campus with a shared interest in renal cancer research. His research is focused on the key clinical questions in initially localised RCC, namely: early detection/screening, early diagnosis approaches, optimal follow-up strategies, neoadjuvant and adjuvant therapies.

Professor Stewart’s current research metrics are: over £54 million research grant/clinical trial income and over 150 peer reviewed publications.

Professor Stewart took up his Chair in 2020, having moved to Cambridge in October 2015 from a post as Senior Lecturer in Urological Surgery at the University of Edinburgh where he led the Edinburgh Urological Cancer Group. Grant developed and still co-directs the Scottish Collaboration On Translational Research into Renal Cell Cancer (SCOTRRCC), a Scotland-wide kidney cancer biorepository of 1200 patients with high quality clinical data linkage.

Professor Stewart is Chair of the Scientific and Education Committee of The Urology Foundation, is a member of the Clinical Expert Review Panel of Cancer Research UK, Trustee of Kidney Cancer UK, Editorial Board member of the BJUI and is CI/PI for several renal cancer clinical trials.

Key publications

COVIDSurg Collaborative (incl G.D. Stewart, dissemination committee). Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study. Anaesthesia. 2021 Mar 9. Online ahead of print

COVIDSurg Collaborative (incl G.D. Stewart, writing group). Elective cancer surgery in COVID-19 free surgical pathways during the SARS-CoV-2 pandemic: An international, multi-centre, comparative cohort study. Journal of Clinical Oncology. 2021;39(1):66-78.

T. Eisen, E. Frangou, B. Oza, A. Ritchie, B. Smith, R. Kaplan, I.D. Davis, M.R. Stockler, L. Albiges, B. Escudier, J. Larkin, A. Bex, S. Joniau, B. Hancock, G.G. Hermann, J. Bellmunt, E. Hodgkinson, G.D. Stewart, J. Barber, J. Brown, R. McMenemin, P. Nathan, L.M. Pickering, M.K.B. Parmar, A. Meade. Adjuvant Sorafenib for Renal Cell Carcinoma at Intermediate or High-Risk of Relapse: Results from the SORCE Randomised Phase III Intergroup Trial. Journal of Clinical Oncology. 2020;38(34):4064-4075.

COVIDSurg Collaborative (incl G.D. Stewart, dissemination committee). Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study. The Lancet. 2020;396(10243):27-38.

J.C.M. Wan, K. Heider, D. Gale, S. Murphy, E. Fisher, F. Mouliere, A. Ruiz-Valdepenas, A. Santonja, J. Morris, D. Chandrananda, A. Marshall, A.B. Gill, P.Y. Chan, E. Barker, G. Young, W.N. Cooper, I. Hudecova, F. Marass, R. Mair, K.M. Brindle, G.D. Stewart, J. Abraham, C. Caldas, D.M. Rassl, R.C. Rintoul, C. Alifrangis, M.R. Middleton, F.A. Gallagher, C. Parkinson, A. Durrani, U. McDermott, C.G. Smith, C. Massie, P.G. Corrie, N. Rosenfeld. ctDNA monitoring to parts per million using patient-specific sequencing and integration of variant reads. Science Translational Medicine. 2020. 2020;12(548):eaaz8084.

C.G. Smith, T. Moser, F. Mouliere, J. Field-Rayner, M. Eldridge, A.L. Riediger, D. Chandrananda, K. Heider, J.C.M. Wan, A.Y. Warren, J. Morris, I. Hudecova, W.N. Cooper, T.J. Mitchell, D. Gale, A. Ruiz-Valdepenas, T. Klatte, S. Ursprung, E. Sala, A.C.P. Riddick, T.F. Aho, J.N. Armitage, S. Perakis, M. Pichler, M. Seles, G. Wcislo, S.J. Welsh, A. Matakidou, T. Eisen, C.E. Massie, N. Rosenfeld, E. Heitzer, G.D. Stewart. Comprehensive characterisation of cell-free tumour DNA in plasma and urine of patients with renal tumours. Genome Medicine. 2020;12(1):23.

T.H.H. Coorens, T.D. Treger, R. Al-Saadi, L. Moore, M.G.B. Tran, T.J. Mitchell, S. Tugnait, C. Thevanesan, M.D. Young, T.R.W. Oliver, M. Oostveen, G. Collord, P.S. Tarpey, A. Cagan, Y. Hooks, M. Brougham, B.C. Reynolds, G. Barone, J. Anderson, M. Jorgensen, G.A.A. Burke, J. Visser, J.C. Nicholson, N. Smeulders, I. Mushtaq, G.D. Stewart, P.J. Campbell, D.C. Wedge, I. Martincorena, D. Rampling, L. Hook, A.Y. Warren, N. Coleman, T. Chowdhury, N. Sebire, J. Drost, K. Saeb-Parsy, M.R. Stratton, K. Straathof, K. Pritchard-Jones, S. Behjati. Embryonal precursors of Wilms tumor. Science. 2019; 366: 1247–1251.

T. Klatte, K. Gallagher, L. Afferi, A. Volpe, N. Kroeger, S. Ribback, A. McNeill, A.C. Riddick, J.N. Armitage, T.F. ‘Aho, T. Eisen, K. Fife, A. Bex, A.J. Pantuck, G.D. Stewart. The VENUSS prognostic model to predict disease recurrence following surgery for non-metastatic papillary renal cell carcinoma: development and evaluation using the ASSURE prospective clinical trial cohort. BMC Medicine. 2019;17(1):182.

S.H. Rossi, T. Klatte, J.A. Usher-Smith, K. Fife, S.J. Welsh, S. Dabestani, A. Bex, D. Nicol, P. Nathan, G.D. Stewart (joint senior author), E.C.F. Wilson. A decision analysis evaluating screening for kidney cancer using focused renal ultrasound. European Urology Focus. 2019;S2405-4569(19)30277-9.

M.D. Young, T.J. Mitchell, F.A. Vieira Braga, M.G.B. Tran, B.J. Stewart, J. Ferdinand, G. Collord, R.A. Botting, D-M. Popescu, K.W. Loudon, R. Vento-Tormo, E. Stephenson, A. Cagan, S. Farndon, M. Del Castillo Velasco-Herrera, C. Guzzo, N. Richoz, L. Mamanova, T. Aho, J.N. Armitage, A.C.P. Riddick, I. Mushtaq, S. Farrell, D. Rampling, J. Nicholson, A. Filby, J. Burge, S. Lisgo, P.H. Maxwell, S. Lindsay, A.Y. Warren, G.D. Stewart, N. Sebire, N. Coleman, M. Haniffa, S. Teichmann, M. Clatworthy, S. Behjati. Single cell transcriptomes from human kidneys reveal the cellular identity of renal tumors. Science. 2018; 361: 594–599.

P. Rodrigues, S.A. Patel, L. Harewood, I. Olan, E. Vojtasova, S.E. Syafruddin, M.N. Zaini, E.K. Richardson, J. Burge, A.Y. Warren, G.D. Stewart, K. Saeb-Parsy, S.A. Samarajiwa, S. Vanharanta. NF-kappaB-dependent lymphoid enhancer co-option promotes renal carcinoma metastasis. Cancer Discovery. 2018. 8:850-865.

T.J. Mitchell, S. Turajlic, A. Rowan, D. Nicol, J.H.R. Farmery, T. O’Brien, I. Martincorena, P. Tarpey, N. Angelopoulos, L.R. Yates, A.P. Butler, K. Raine, G.D. Stewart, B. Challacombe, A. Fernando, J. I. Lopez, S. Hazell, A. Chandra, S. Chowdhury, S. Rudman, A. Soultati, G. Stamp, N. Fotiadis, L. Pickering, L. Au, L. Spain, J. Lynch, M. Stares, J. Teague, F. Maura, D.C. Wedge, S. Horswell, T. Chambers, K. Litchfield, H. Xu, A. Stewart, R. Elaidi, S. Oudard, N. McGranahan, I. Csabai, M. Gore, P.A. Futreal, J. Larkin, A.G. Lynch, Z. Szallasi, C. Swanton, P.J. Campbell, on behalf of the Renal TRACERx consortium. Timing the landmark events in the evolution of clear cell renal cell carcinoma: TRACERx Renal. Cell. 2018; 173(3): 611-623.

A.L.R. Lubbock, G.D. Stewart (joint 1st author), F.C. O’Mahony, A. Laird, P. Mullen, M. O’Donnell, T. Powles, D.J. Harrison, I.M. Overton. Overcoming intratumoural heterogeneity for reproducible molecular risk stratification: a case study in advanced kidney cancer. BMC Medicine. 2017. 15(1):118.

S.H. Rossi, R. Hsu, C. Blick, V. Goh, P. Nathan, D. Nicol, S. Fleming, M. Sweeting, E.C.F. Wilson, G.D. Stewart. A meta-analysis of the prevalence of renal cancer detected by abdominal ultrasonography in asymptomatic individuals. British Journal of Surgery. 2017; 104: 648–659.

G.D. Stewart, F.C. O’Mahony, A. Laird, L. Eory, A.L.R. Lubbock, A. Mackay, J. Nanda, M. O’Donnell, P. Mullen, S.A. McNeill, A.C.P. Riddick, D. Berney, A. Bex, M. Aitchison, I.M. Overton, D.J. Harrison, T. Powles. Sunitinib treatment exacerbates intratumoral heterogeneity in metastatic renal cancer. Clinical Cancer Research. 2015; 21(18): 4212–23.

G.D. Stewart, F.C. O’Mahony, A. Laird, S. Rashid, S.A. Martin, L. Eory, A.L.R. Lubbock, J. Nanda, M. O’Donnell, A. Mackay, P. Mullen, S.A. McNeill, A.C.P. Riddick, M. Aitchison, D. Berney, A. Bex, I.M. Overton, D.J. Harrison, T. Powles. Carbonic anhydrase 9 expression increases with VEGF targeted therapy and is predictive of outcome in metastatic clear cell renal cancer. European Urology. 2014; 66: 956-963.

K. Sharpe, G.D. Stewart (joint 1st author), A. Mackay, C. Van Neste, C. Rofe, D.M. Berney, I. Kayani, A. Bex, E. Wan, F. O’Mahony, M. O’Donnell, S. Chowdhury, R. Doshi, C. Ho Yen, M. Gerlinger, D. Baker, N.R. Smith, B.R. Davies, A. Sahdev, E. Boleti, T. de Meyer, W. Van Criekinge, L. Beltran, Y-J. Lu, D. Harrison, A.R. Reynolds, T. Powles. The effect of VEGF targeted therapy on biomarker expression in sequential tissue from patients with metastatic clear cell renal cancer. Clinical Cancer Research. 2013; 19: 6924-6934.

Areas of expertise

kidney cancer, renal cell cancer, translational research, biomarker development, clinical trials, window-of-opportunity trials, neoadjuvant trials, adjuvant trials, screening, device trials.