University Reader; Honorary Transplant Consultant
Mr Kourosh Saeb-Parsy joined the Department of Surgery in 2007 as a Clinical Lecturer and was appointed as University Lecturer and Honorary Consultant Transplant Surgeon in 2012. He was appointed as Reader in Transplantation in 2018. He has also been a Fellow and Director of Studies in Clinical Medicine at Fitzwilliam College since 2003.
His laboratory research interests are focused on the cellular and humoral immune response to transplantation, the impact of ischaemia reperfusion injury on acute and chronic graft function, and the immunogenicity of stem cells and their derivatives. His clinical research is directed towards identification of donor and recipient factors that can affect graft and patient outcomes after kidney, pancreas and liver transplantation.
His collaborative, multidisciplinary and translational research program is focused on:
- Function and immunogenicity of transplanted regenerative cellular therapies
- Ischaemia-reperfusion injury in transplantation
- Translational research using human tissue
- Clinical outcomes after transplantation
Website: Saeb-Parsy Lab
Martincorena I, Fowler JC, Wabik A, Lawson ARJ, Abascal F, Hall MWJ, Cagan A, Murai K, Mahbubani K, Stratton MR, Fitzgerald RC, Handford PA, Campbell PJ, Saeb-Parsy K, Jones PH. Somatic mutant clones colonize the human esophagus with age. Science (2018) Nov 23; 362(6417): 911-917.
Broutier L, Mastrogiovanni G, Verstegen GMA, Francies HE, Morrill E, Bradshaw CR, Allen GE, Arnes R, Gaspersz MP, Georgakopoulos N, Koo B-K, Dietman S, Davies SE, Praseedom R, de Jonge J, IJzermans JNM, Wigmore SJ, Saeb-Parsy K, Garnett MJ, van der Laan LJW, Huch M. Tumour-derived Organoid Cultures model Primary Human Liver Cancer in vitro. Nature Medicine (2017) 23(12):1424-1435.
Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL, de Brito MC, Berntsen NL, Gómez-Vázquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J, Bertero A, Zonneveld MCF, Pedersen MT, Pawlowski M, Valestrand L, Madrigal P, Georgakopoulos N, Pirmadjid N, Skeldon GM, Casey J, Shu W, Materek PM, Snijders KE, Brown SE, Rimland CA, Simonic I, Davies SE, Jensen KB, Zilbauer M, Gelson WTH, Alexander A, Sinha S, Hannan NRF, Wynn TA, Karlsen TH, MelumE, Markaki4 AE, Saeb-Parsy K*, Vallier L*. Reconstruction of the murine extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nature Medicine (2017) 23(8):954-963 (* equal contribution).
Sampaziotis F, Brito MC, Bertero A, Madrigal P, Saeb-Parsy K, Soares F, Schrumpf E, Melum E, Karlsen TH, Bradley JA, Gelson WTH, Davies S, Baker A, Kaser A, Alexander GJ, Hannan NRF, Vallier L (2015) Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation. Nature Biotechnology 33: 845-52.
Dyson M, Watson CJ, Liddell K, Padfield N, Bradley JA, Saeb-Parsy K (2015) Transplanting suboptimum organs: medico-legal implications. Lancet 386: 719-21.
Chouchani ET, Pell VR, Gaude E, Aksentijevic´ D, Sundier SY, Robb EL, Logan A, Nadtochiy AM, Ord ENJ, Smith AC, Eyassu F, Shirley R, Hu C-H, Dare AJ, James AM, Rogatti S, Hartley RC, Eaton S, Costa ASH, Brookes PS, Davidson SM, Duchen MR, Saeb-Parsy K, Shattock MJ, Robinson AJ, Work LM, Frezza C, Krieg T, Murphy MP (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature. 515(7527):431-5.
Chouchani ET, Pell VR, James AM, Work LM, Saeb-Parsy K, Frezza C, Kreig T, Murphy M (2016) A unifying mechanism for mitochondrial superoxide production during ischaemia-reperfusion injury. Cell Metabolism 23: 254-63.
Hakeem A, Chen J, Iype S, Clatworthy M, Watson C, Godfrey EM, Upponi S, Saeb-Parsy K (2018) Pancreatic Allograft Thrombosis: Suggestion for a CT grading system and management algorithm. American Journal of Transplantation 18(1):163-179.
Hamed MO, Chen Y, Pasea L, Watson CJ, Torpey N, Bradley JA, Pettigrew GJ, Saeb-Parsy K (2015) Early graft loss after kidney transplantation: risk factors and consequences. American Journal of Transplantation 15:1632-43.
Rodrigues P, Patel SA, Harewood L, Olan I, Vojtasova E, Syafruddin SE, Zaini MN, Richardson EK, Burge J, Warren AY, Stewart GD, Saeb-Parsy K, Samarajiwa SA, Vanharanta S (2018). NF-κB-Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis. Cancer Discovery.8(7):850-86