Professor of Transplantation (Honorary Consultant)
Biography/Research interests
Professor Kourosh Saeb-Parsy joined the Department of Surgery in 2007 as a Clinical Lecturer and was appointed as University Lecturer and Honorary Consultant Transplant Surgeon in 2012. He was appointed as Reader in Transplantation in 2018. He has also been a Fellow and Director of Studies in Clinical Medicine at Fitzwilliam College since 2003.
His laboratory research interests are focused on the cellular and humoral immune response to transplantation, the impact of ischaemia reperfusion injury on acute and chronic graft function, and the immunogenicity of stem cells and their derivatives. His clinical research is directed towards identification of donor and recipient factors that can affect graft and patient outcomes after kidney, pancreas and liver transplantation.
His collaborative, multidisciplinary and translational research program is focused on:
- Function and immunogenicity of transplanted regenerative cellular therapies
- Ischaemia-reperfusion injury in transplantation
- Translational research using human tissue
- Clinical outcomes after transplantation
Website: Saeb-Parsy Lab
Key publications
Moore L, Leongamornlert D, Coorens THH, Sanders MA, Ellis P, Dentro S, Dawson K, Butler T, Rahbari R, Mitchell TJ, Maura F, Nangalia J, Tarpey PS, Brunner SF, Lee-Six H, Hooks Y, Moody S, Mahbubani K, Jimenez-Linan M, Brosens JJ, Lacobuzio-Donahue CA, Martincorena I, Saeb-Parsy K, Campbell PJ, Stratton MR. (2020) The mutational landscape of normal human endometrial epithelium. Nature 580, 640–646. press release
Park JE, Botting RA, Domínguez Conde C, Popescu DM, Lavaert M, Kunz DJ, Goh I, Stephenson E, Ragazzini R, Tuck E, Wilbrey-Clark A, Roberts K, Kedlian VR, Ferdinand JR, He X, Webb S, Maunder D, Vandamme N, Mahbubani KT, Polanski K, Mamanova L, Bolt L, Crossland D, de Rita F, Fuller A, Filby A, Reynolds G, Dixon D, Saeb-Parsy K, Lisgo S, Henderson D, Vento-Tormo R, Bayraktar OA, Barker RA, Meyer KB, Saeys Y, Bonfanti P, Behjati S, Clatworthy MR, Taghon T, Haniffa M, Teichmann SA. (2020) A cell atlas of human thymic development defines T cell repertoire formation. Science. 2020 Feb 21;367(6480).
James KR, Gomes T, Elmentaite R, Kumar N, Gulliver EL, King HW, Stares MD, Bareham BR, Ferdinand JR, Petrova VN, Polański K, Forster SC, Jarvis LB, Suchanek O, Howlett S, James LK, Jones JL, Meyer KB, Clatworthy MR, Saeb-Parsy K, Lawley TD, Teichmann SA. (2020) Distinct microbial and immune niches of the human colon. Nature Immunology. 2020 Mar;21(3):343-353.
Coorens THH, Treger TD, Al-Saadi R, Moore L, Tran MGB, Mitchell TJ, Tugnait S, Thevanesan C, Young MD, Oliver TRW, Oostveen M, Collord G, Tarpey PS, Cagan A, Hooks Y, Brougham M, Reynolds BC, Barone G, Anderson J, Jorgensen M, Burke GAA, Visser J, Nicholson JC, Smeulders N, Mushtaq I, Stewart GD, Campbell PJ, Wedge DC, Martincorena I, Rampling D, Hook L, Warren AY, Coleman N, Chowdhury T, Sebire N, Drost J, Saeb-Parsy K, Stratton MR, Straathof K, Pritchard-Jones K, Behjati S. (2019) Embryonal precursors of Wilms tumor. Science. 2019 Dec 6;366(6470):1247-1251
Martin JL, Costa ASH, Gruszczyk AV, Beach TE, Allen FM, Prag HA, Hinchy EC, Mahbubani K, Hamed M, Tronci L, Nikitopoulou E, James AM, Krieg T, Robinson AJ, Huang MM, Caldwell ST, Logan A, Pala L, Hartley RC, Frezza C, Saeb-Parsy K*, Murphy MP* (2019) Succinate accumulation drives ischaemia reperfusion injury during organ transplantation. Nature Metabolism 1;966-974. * Equal contribution
