Professor of Transplant Surgery and Honorary Consultant Surgeon
Professor Nicholson is a transplant and endocrine surgeon with a specialist interest in live donor nephrectomy and renal transplantation. His research interests are in the fields of normothermic organ preservation and ischaemia-reperfusion injury. His group was the first to perform renal transplants after ex vivo normothermic perfusion (EVNP).
He is the Director of the NIHR Blood and Transplant Research Unit (BTRU) in Organ Donation and Transplantation (core funding £3.8 million over 5 years). The aim of the BTRU is to develop new approaches and technologies in transplantation that increase the number of donor organs and improve allograft survival.
Professor Nicholson is a Professorial Fellow in Medicine at St Catharine’s College.
Key Publications
O’Keefe LM, Ramond A, Oliver-Williams C, Willeit P, Paige E, Trotter P, Evans J, Wadstrom J, Nicholson M, Collett D, Di Angelantonio E. Medium and long-term health risks in living kidney donors: a systematic review and meta-analysis. Annals of Internal Medicine (2018 in press).
Hosgood SA, Thompson E, Moore T, Wilson CH, Nicholson ML (2017) Normothermic machine perfusion for the assessment and transplantation of declined human kidneys from donation after circulatory death donors. British Journal of Surgery Dec 6 [Epub ahead of print]
Tietjen GT, Hosgood SA, DiRito J, Cui J, Deep D, Song E, Kraehling JR, Piotrowski-Daspit AS, Kirkiles-Smith NC, Al-Lamki R, Thiru S, Bradley JA, Saeb-Parsy K, Bradley JR, Nicholson ML, Saltzman WM, Pober JS. (2017) Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys. Science Translational Medicine 9:418–27.
Hosgood SA, Saeb-Parsy K, Hamed MO, Nicholson ML.(2016) Successful Transplantation of Human Kidneys Deemed Untransplantable but Resuscitated by Ex Vivo Normothermic Machine Perfusion. American Journal of Transplantation 16:3282–3285.
Hosgood SA, Barlow AD, Hunter JP, Nicholson ML.(2015) Ex-vivo normothermic perfusion for quality assessment of marginal donor kidney transplants. British Journal of Surgery 102:1433–40.
Hunter JP, Hosgood SA, Barlow AD, Nicholson ML.(2015) Ischaemic conditioning reduces kidney injury in an experimental large-animal model of warm renal ischaemia. British Journal of Surgery 102:1517–25.
Nicholson ML, Pattenden CJ, Barlow AD, Hunter JP, Lee G, Hosgood SA. (2015)A Double Blind Randomized Clinical Trial of Remote Ischemic Conditioning in Live Donor Renal Transplantation. Medicine 2015;94:1316–21.
Nicholson ML, Hosgood SA.(2013) Renal transplantation after ex vivo normothermic perfusion: the first clinical study. American Journal of Transplantation 13:1246–52.
Hosgood SA, Thiyagarajan UM, Nicholson HF, Jeyapalan I, Nicholson ML.(2012) Randomized clinical trial of transversus abdominis plane block versus placebo control in live-donor nephrectomy. Transplantation. 94:520–5.
Nicholson ML, Kaushik M, Lewis GR, Brook NR, Bagul A, Kay MD, Harper SJ, Elwell R, Veitch PS.(2010) Randomized clinical trial of laparoscopic versus open donor nephrectomy.
British Journal of Surgery 97:21–8.
