PhD Student; Research Assistant
Biography/Research interests
Mr Georgakopoulos is currently undertaking his PhD in Regenerative Medicine under the supervision of Mr Kourosh Saeb-Parsy (Department of Surgery) and Meritxell Huch (MPI-CBG, Dresden, Germany; Gurdon Institute, Cambridge, UK). The project aims to study the efficacy and immunogenicity of adult derived pancreatic stem cells as a cellular therapy for diabetes. This model of therapy aims to work alongside or replace clinical islet transplantation.
He completed his bachelor’s degree in Biochemistry at the University of Southampton. He then moved to Cambridge and for the past two years has been working as a research assistant in the Department of Surgery as well as coordinator of the Cambridge Biorepository for Translational Medicine
Key Publications
Georgakopoulos N, Prior N, Angres B, Mastrogiovanni G, Cagan A, Harrison D, Hindley CJ, Arnes-Benito R, Liau SS, Curd A, Ivory N, Simons BD, Martincorena I, Wurst H, Saeb-Parsy K, Huch M. Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids. BMC Dev Biol. 2020 Feb;20(1) 4. doi:10.1186/s12861-020-0209-5. PMID: 32098630; PMCID: PMC7043048.
Rimland CA, Tilson SG, Morell CM, Tomaz RA, Lu WY, Adams SE, Georgakopoulos N, Otaizo-Carrasquero F, Myers TG, Ferdinand JR, Gieseck RL, Sampaziotis F, Tysoe OC, Wesley B, Muraro D, Oniscu GC, Hannan NR, Forbes SJ, Saeb-Parsy K, Wynn TA, Vallier L. Regional differences in human biliary tissues and corresponding in vitro derived organoids. Hepatology. 2020 Mar . doi:10.1002/hep.31252. PMID: 32222998.
Madissoon E, Wilbrey-Clark A, Miragaia RJ, Saeb-Parsy K, Mahbubani KT, Georgakopoulos N, Harding P, Polanski K, Huang N, Nowicki-Osuch K, Fitzgerald RC, Loudon KW, Ferdinand JR, Clatworthy MR, Tsingene A, van Dongen S, Dabrowska M, Patel M, Stubbington MJT, Teichmann SA, Stegle O, Meyer KB. scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation. Genome Biol. 2019 Dec;21(1) 1. doi:10.1186/s13059-019-1906-x. PMID: 31892341; PMCID: PMC6937944.
Lee-Six H, Olafsson S, Ellis P, Osborne RJ, Sanders MA, Moore L, Georgakopoulos N, Torrente F, Noorani A, Goddard M, Robinson P, Coorens THH, O’Neill L, Alder C, Wang J, Fitzgerald RC, Zilbauer M, Coleman N, Saeb-Parsy K, Martincorena I, Campbell PJ, Stratton MR. The landscape of somatic mutation in normal colorectal epithelial cells. Nature. 2019 Oct;574(7779) 532-537. doi:10.1038/s41586-019-1672-7. PMID: 31645730.
Broutier L, Mastrogiovanni G, Verstegen MM, Francies HE, Gavarró LM, Bradshaw CR, Allen GE, Arnes-Benito R, Sidorova O, Gaspersz MP, Georgakopoulos N, Koo BK, Dietmann S, Davies SE, Praseedom RK, Lieshout R, IJzermans JNM, Wigmore SJ, Saeb-Parsy K, Garnett MJ, van der Laan LJ, Huch M. Human primary liver cancer-derived organoid cultures for disease modeling and drug screening. Nat Med. 2017 Dec;23(12) 1424-1435. doi:10.1038/nm.4438. PMID: 29131160; PMCID: PMC5722201.
Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL, de Brito MC, Berntsen NL, Gómez-Vázquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J, Bertero A, Zonneveld MCF, Pedersen MT, Pawlowski M, Valestrand L, Madrigal P, Georgakopoulos N, Pirmadjid N, Skeldon GM, Casey J, Shu W, Materek PM, Snijders KE, Brown SE, Rimland CA, Simonic I, Davies SE, Jensen KB, Zilbauer M, Gelson WTH, Alexander GJ, Sinha S, Hannan NRF, Wynn TA, Karlsen TH, Melum E, Markaki AE, Saeb-Parsy K, Vallier L. Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nat Med. 2017 Aug;23(8) 954-963. doi:10.1038/nm.4360. PMID: 28671689.
