Hunterian Professor (2019) – Royal College of Surgeons of England
The ability to image pathobiology of atherosclerosis has been a fundamental driver of the paradigm shift in the way atherosclerosis is viewed today as a systemic inflammatory disease with an immunological basis. Imaging with techniques such as magnetic resonance imaging has allowed us to unravel the pathology of atherosclerosis and monitor efficacy of known and novel pharmacotherapies targeted at atherosclerosis. We have developed imaging platforms which allow morphological and functional assessment of atherosclerosis related-neovascularisation and inflammation. Significant body of work by the bioengineers within our group has allowed imaging based ex vivo and in vivo assessment of haemodynamic factors that influence atherosclerotic disease process. Our current focus is development of novel techniques that allow cellular imaging of mediators of atherosclerosis. Our bioengineering wing aims to analyse existing endovascular technologies such as aortic stents in terms of their effective durability with a view to develop the next generation of durable endovascular (bio)prosthesis.
Usman A, Yuan J, Patterson AJ, Graves MJ, Varty K, Sadat U, Gillard JH (2018), “Neovascularization in Vertebral Artery Atheroma-A Dynamic Contrast-Enhanced Magnetic Resonance Imaging-Based Comparative Study in Patients with Symptomatic and Asymptomatic Carotid Artery Disease.” J Stroke Cerebrovasc Dis 27(9):2505-2512
Wang S, Zhang Y, Feng J, Huang Y, Tokgoz A, Sadat U, Gillard JH, Lu Q, Teng Z (2017), “Influence of overlapping pattern of multiple overlapping uncovered stents on the local mechanical environment: A patient-specific parameter study.” J Biomech 60:188-196
Sadat U, Jaffer FA, van Zandvoort MA, Nicholls SJ, Ribatti D, Gillard JH (2014), “Inflammation and neovascularization intertwined in atherosclerosis: imaging of structural and molecular imaging targets.” Circulation 130(9):786-94
Li ZY, Sadat U, U-King-Im J, Tang TY, Bowden DJ, Hayes PD, Gillard JH (2010), “Association between aneurysm shoulder stress and abdominal aortic aneurysm expansion: a longitudinal follow-up study.” Circulation 122(18):1815-22
Sadat U, Taviani V, Patterson AJ, Young VE, Graves MJ, Teng Z, Tang TY, Gillard JH (2010), “Ultrasmall Superparamagnetic Iron Oxide-enhanced Magnetic Resonance Imaging of Abdominal Aortic Aneurysms-A Feasibility Study.” Eur J Vasc Endovasc Surg
Sadat U, Teng Z, Young VE, Walsh SR, Li ZY, Graves MJ, Varty K, Gillard JH (2010), “Association between biomechanical structural stresses of atherosclerotic carotid plaques and subsequent ischaemic cerebrovascular events–a longitudinal in vivo magnetic resonance imaging-based finite element study.” Eur J Vasc Endovasc Surg 40(4):485-91