2020
Bottle A, Griffiths R, White S, Davies BM, et al. Periprosthetic fractures: the next fragility fracture epidemic? A national observational study. BMJ Open. 2020 Dec 10;10(12):e042371.
Eisen T, Frangou E, Oza B, Stewart GD, et al. Adjuvant Sorafenib for Renal Cell Carcinoma at Intermediate or High Risk of Relapse: Results From the SORCE Randomized Phase III Intergroup Trial. J. Clin. Oncol. 2020 Dec 1;38(34):4064-4075.
Sushentsev N, Kaggie JD, Buonincontri G, Schulte RF, Graves MJ, Gnanapragasam VJ, Barrett T. The effect of gadolinium-based contrast agent administration on magnetic resonance fingerprinting-based T 1 relaxometry in patients with prostate cancer. Sci Rep. 2020 Nov 24;10(1):20475.
Caglic I, Sushentsev N, Gnanapragasam VJ, et al. MRI-derived PRECISE scores for predicting pathologically-confirmed radiological progression in prostate cancer patients on active surveillance. Our Radiol. 2020 Nov 16. [Online ahead of print]
Henson F, Lydon H, Birch M, Brooks R, McCaskie A. Using apheresis-derived cells to augment microdrilling in the treatment of chondral defects in an ovine model. J Orthop Res. 2020 Nov 4. [Online ahead of print]
Matas‐Céspedes A, Brown L, Mahbubani K, Saeb-Parsy K et al. Use of human splenocytes in an innovative humanised mouse model for prediction of immunotherapy‐induced cytokine release syndrome. Clinical & Translational Immunology. 2020 Nov 4; 9(e1202)
Gupta I, Cassará AM, Tarotin I, Donega M, Dolezalova N, Saeb-Parsy K, et al. Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves. Commun Biol. 2020 Oct 16;3(1):577.
Cunniffe NG, Gunter SJ, Brown M, Stewart GD, et al. How achievable are COVID-19 clinical trial recruitment targets? A UK observational cohort study and trials registry analysis. BMJ Open 2020 Oct 5;10(10):e044566.
Lawson ARJ, Abascal F, Mahbubani KT, Bareham B, Gnanapragasam V, Saeb-Parsy K, Mitchell T, et al. Extensive heterogeneity in somatic mutation and selection in the human bladder. Science. 2020 Oct 2;Vol. 370, Issue 6512, pp. 75-82.
Guldvik IJ, Zuber V, Braadland PR, Gnanapragasam V, et al. Identification and Validation of Leucine-rich a-2-glycoprotein 1 as a Noninvasive Biomarker for Improved Precision in Prostate Cancer Risk Stratification. European Urology Open Science. 2020 Oct; Vol.21:51-60
Atici SD, Kaya T, Aydin C, Stewart GD, et al. Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic. British Journal of Surgery 2020 Oct
Litviňuková M, Talavera-López C, Maatz H, Saeb-Parsy K, Mahbubani KT, et al. Cells of the adult human heart. Nature. 2020 Sep 24. [Online ahead of print]
Jordan NP, Nicholson ML, Hosgood SA. MicroRNA-126-3p is Downregulated in Human Kidneys in a Model of Reperfusion Injury. Kidney International Reports. 2020 Sep 23;5(12) P2357-2360.
Saeb-Parsy K, Martin JL, Summers DM, Watson CJE, Krieg T, Murphy MP. Mitochondria as Therapeutic Targets in Transplantation. Trends Mol Med. 2020 Sep 17;S1471-4914(20)30190-8. [Online ahead of print]
Lim JA, Loh B, Sylvestor G, Khan W. Perioperative management of distal radius fractures. J Perioper Pract. 2020 Sep 8;1750458920949463. [Online ahead of print]
Eldridge SE, Barawi A, Wang H, Roelofs A, Henson F, McCaskie AM, De Bari C, et al. Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis. Science Translational Medicine. 2020 Sep 2;12(559) eaax9086
Crispin-Ortuzar M, Gehrung M, Ursprung S, Stewart G, Mitchell T, et al. Three-Dimensional Printed Molds for Image-Guided Surgical Biopsies: An Open Source Computational Platform Licensed under the Creative Commons Attribution 4.0 License. JCO Clinical Cancer Informatics. August 2020; 4(4):736-748
Usher-Smith J, Simmons RK, Rossi S, Stewart GD. Current evidence on screening for renal cancer. Nature Reviews Urology. 2020 Aug 28 [online]
Darst BF, Dadaev T, Saunders EJ, Gnanapragasam VJ et al. Germline sequencing DNA repair genes in 5,545 men with aggressive and non-aggressive prostate cancer. J Natl Cancer Inst. 2020 Aug 27;djaa132. [Online ahead of print]
Prag HA, Gruszczyk AV, Huang MM, Beach TE, Saeb-Parsy K et al. Mechanism of succinate efflux upon reperfusion of the ischemic heart. Cardiovasc Research. 2020 Aug 7;cvaa148. [Online ahead of print]
Noble S, Garfield K, Gnanapragasam VJ et al. The ProtecT randomised trial cost-effectiveness analysis comparing active monitoring, surgery, or radiotherapy for prostate cancer. Br J Cancer. 2020 Jul 16 [Epub ahead of print]
Harrison H, Thompson RE, Lin Z, Rossi SH, Stewart GD, Griffin SJ, Usher-Smith JA. Risk Prediction Models for Kidney Cancer: A Systematic Review. Eur Urol Focus. 2020 Jul 14:S2405-4569(20)30190-5 [Epub ahead of print]
Prag HA, Pala L, Kula-Alwar D, Saeb-Parsy K, Beach TE, et al. Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo. Cardiovasc Drugs Ther. 2020 July 9 [Epub ahead of print]
Bentley S, Johnson C, Exall E, Brohan E, Lawrance R, Bennett B, Bargo D, Zanotti G, Staehler M, Stewart G.
Improving patient-clinician communication following nephrectomy in Renal Cell Carcinoma: Development, content validation and pilot testing of a Conversation Aid Tool. Patient Education and Counseling. 2020 June 30 [online]
Ayorinde JOO, Saeb-Parsy K, Hossain A. Opportunities and Challenges in Using Social Media in Organ Donation. JAMA Surg. 2020 June 17 [online]
Wan JCM, Stewart GD et al. ctDNA Monitoring Using Patient-Specific Sequencing and Integration of Variant Reads Sci Transl Med. 2020 Jun 17;12(548):eaaz8084.
Thurtle D, Bratt Ola, Stattin P, Pharoah P, Gnanapragasam VJ. Comparative performance and external validation of the multivariable PREDICT Prostate tool for non-metastatic prostate cancer: A study in 69,206 men from Prostate Cancer data Base Sweden (PCBaSe). BMC Med. 2020 Jun 16;18(1):139.
Gnanapragasam VJ, Leonard K, Sut M, Ilie C, Ord J, Roux J, Prieto MCH, Warren A, Tamer P. Multicentre clinical evaluation of the safety and performance of a simple transperineal access system for prostate biopsies for suspected prostate cancer: The CAMbridge PROstate Biopsy DevicE (CamPROBE) study. Journal of Clinical Urology. 2020 June 12 [Epub ahead of print]
To K, Romain K, Mak C, Kamaraj A, Henson F, Khan W. The Treatment of Cartilage Damage Using Human Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Systematic Review of in vivo Studies. Front Bioeng Biotechnol 2020 Jun 11;8:580. [eCollection 2020]
Zawaideh JP, Sala E, Pantelidou M, Shaida N, Koo B, Caglic I, Warren AY, Carmisciano L, Saeb-Parsy K, Gnanapragasam VJ, Kastner C, Barrett T. Comparison of Likert and PI-RADS Version 2 MRI Scoring Systems for the Detection of Clinically Significant Prostate Cancer. Radiol. 2020 Jun 1;20200298. [Epub ahead of print]
Parry MG, Cowling TE, Sujenthiran A, Nossiter J, Berry B, Cathcart P, Aggarwal A, Payne H, van der Meulen J, Clarke NW, Gnanapragasam VJ. Risk stratification for prostate cancer management: value of the Cambridge Prognostic Group. BMC Med. 2020 May 28;18(1):114.
Green M, Byrne MHV, Legard C, Chen E, Critchley A, Stainer B, Chaggar H, Symington M, Hu L, Brathwaite-Shirley C, Mayes J, Mogg JAW, Murphy J, Saeb-Parsy K. The Effect of Positive and Negative Poster Messages on Organ Donor Registration. Transplant Proc. 2020 May 16:S0041-1345(20)30280-3.[Epub ahead of print]
Tambur AR, Campbell P, Chong AS, Feng S, Ford ML, Gebel H, Gill RG, Kelsoe G, Kosmoliaptsis V, Mannon RB, Mengel M, Reed EF, Valenzuela NM, Wiebe C, Dijke E, Sullivan HC, Nickerson P. Sensitization in Transplantation: Assessment of Risk (STAR) 2019 Working Group Meeting Report. Am J Transplant. 2020 Apr 27. [Epub ahead of print]
Sungnak W, Huang N, Bécavin C, Berg M, Queen R, Litvinukova M, Talavera-López C, Maatz H, Reichart D, Sampaziotis F, Worlock KB, Yoshida M, Barnes JL; HCA Lung Biological Network. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med. 2020 Apr 23. [Epub ahead of print]
Wajs E, Rughoobur G, Burling K, George A, Flewitt A, Gnanapragasam V. A novel split mode TFBAR devices for quantitative measurements of prostate specific antigen in a small sample of whole blood. Nanoscale. 2020 May 7;12(17):9647-9652. Epub 2020 Apr 22.
Moore L, Leongamornlert D, Coorens THH, Sanders MA, Ellis P, Dentro SC, Dawson KJ, Butler T, Rahbari R, Mitchell TJ, Maura F, Nangalia J, Tarpey PS, Brunner SF, Lee-Six H, Hooks Y, Moody S, Mahbubani KT, Jimenez-Linan M, Brosens JJ, Iacobuzio-Donahue CA, Martincorena I, Saeb-Parsy K, Campbell PJ, Stratton MR. The mutational landscape of normal human endometrial epithelium. Nature. 2020 Apr;580(7805):640-646. [Epub 2020 Apr 22]. press release
Kim L, Boxall N, George A, Burling K, Acher P, Aning J, McCracken S, Page T, Gnanapragasam VJ. Clinical utility and cost modelling of the phi test to triage referrals into image-based diagnostic services for suspected prostate cancer: the PRIM (Phi to RefIne Mri) study. BMC Med. (2020) IF 8.3 Apr 17;18(1):95
Al-Lamki RS, Hudson NJ, Bradley JR, Warren AY, Eisen T, Welsh SJ, Riddick ACP, O’Mahony FC, Turnbull A, Powles T, Scotrrcc Collaborative, Reverter A, Harrison DJ, Stewart GD. The Efficacy of Sunitinib Treatment of Renal Cancer Cells Is Associated with the Protein PHAX In Vitro. Biology (Basel). 2020 Apr 7;9(4). pii: E74.
Hemelrijck MV, Ji X, Helleman J, Roobol M, Nieboer D, Bangma C, Frydenberg M, Rannikko A, Lee LS, Gnanapragasam V, Kattan M and GAP3 Movember Foundation’s Active Surveillance Database. PD62-01 A first step towards a global nomogram to predict disease progression for men on active surveillance. Journal of Urology 2020 April 1; vol.203, Issue Supplement 4
Ellis RJ, Del Vecchio SJ, Gallagher KMJ, Aliano DN, Barber N, Bolton DM, Chew ETS, Coombes JS, Coory MD, Davis ID, Donaldson JF, Francis RS, Giles GG, Gobe GC, Hawley CM, Johnson DW, Laird A, Leung S, Malki M, Marco DJT, McNeill AS, Neale RE, Ng KL, Phipps S, Stewart GD, White VM, Wood ST, Jordan SJ. A Simple Clinical Tool for Stratifying Risk of Clinically Significant CKD after Nephrectomy: Development and Multinational Validation. JASN 2020 April; ASN.2019121328
Hotham WE, Henson FMD. The use of large animals to facilitate the process of MSC going from laboratory to patient-‘bench to bedside’. Cell Biology and Toxicology. 2020 Mar 23 [Epub]
Zawaideh JP, Sala E, Shaida N. Koo B, Warren AY, Carmisciano L, Saeb-Parsy K, Gnanapragasam VJ, Kastner C, Barrett T. Diagnostic accuracy of biparametric versus multiparametric prostate MRI: assessment of contrast benefit in clinical practice. Eur Radiol 2020 March 12; [Epub]
Watson CJE, Johnson RJ, Mumford L. Overview of the Evolution of the UK Kidney Allocation Schemes. Curr Transpl Rep. 2020 March 12; [Epub]
Thomas BC, Slack M, Hussain M, Barber N, Pradhan A, Dinneen E, Stewart GD. Preclinical Evaluation of the Versius Surgical System, a New Robot-assisted Surgical Device for Use in Minimal Access Renal and Prostate Surgery. Eur Urol Focus. 2020 Mar 10. pii: S2405-4569(20)30029-8. [Epub ahead of print]
Park JE, Botting RA, Domínguez Conde C, Popescu DM, Lavaert M, Kunz DJ, Goh I, Stephenson E, Ragazzini R, Tuck E, Wilbrey-Clark A, Roberts K, Kedlian VR, Ferdinand JR, He X, Webb S, Maunder D, Vandamme N, Mahbubani KT, Polanski K, Mamanova L, Bolt L, Crossland D, de Rita F, Fuller A, Filby A, Reynolds G, Dixon D, Saeb-Parsy K, Lisgo S, Henderson D, Vento-Tormo R, Bayraktar OA, Barker RA10, Meyer KB, Saeys Y, Bonfanti P, Behjati S, Clatworthy MR, Taghon T1, Haniffa M, Teichmann SA. A cell atlas of human thymic development defines T cell repertoire formation. Science. 2020 Feb 21;367(6480). pii: eaay3224.
James KR, Gomes T, Elmentaite R, Kumar N, Gulliver EL, King HW, Stares MD, Bareham BR, Ferdinand JR, Petrova VN, Polański K, Forster SC, Jarvis LB, Suchanek O, Howlett S, James LK, Jones JL, Meyer KB, Clatworthy MR, Saeb-Parsy K, Lawley TD, Teichmann SA Distinct microbial and immune niches of the human colon. Nat Immunol. 2020 Feb 17. [Epub ahead of print]
Yong C, Stewart GD. Transcriptomic Signatures Related to the Obesity Paradox in Patients with Clear Cell Renal Cell Carcinoma: A Cohort Study. Eur Urol. 2020 Feb 12. pii: S0302-2838(20)30069-5. [Epub ahead of print]
ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Pan-cancer analysis of whole genomes. Nature. 2020 Feb;578(7793):82-93. (Co-authors: Gnanapragasam VJ, Mitchell T.)
Noorani A, Li X, Goddard M, Crawte J, Alexandrov LB, Secrier M, Eldridge MD, Bower L, Weaver J, Lao-Sirieix P, Martincorena I, Debiram-Beecham I, Grehan N, MacRae S, Malhotra S, Miremadi A, Thomas T, Galbraith S, Petersen L, Preston SD, Gilligan D, Hindmarsh A, Hardwick RH, Stratton MR, Wedge DC, Fitzgerald RC. Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma. Nat Genet. 2020 Jan;52(1):74-83. online aticle
Sushentsev N, Caglic I, Sala E, Shaida N, Slough RA, Carmo B, Kozlov V, Gnanapragasam V, Barrett T. The effect of capped biparametric magnetic resonance imaging slots on weekly prostate cancer imaging workload. Br J Radiol. 2020 Jan 23:20190929.[Epub ahead of print]
de Bruijn R, Wimalasingham A, Szabados B, Stewart GD, Welsh SJ, Kuusk T, Blank C, Haanen J, Klatte T, Staehler M, Powles T, Bex A. Deferred Cytoreductive Nephrectomy Following Presurgical Vascular Endothelial Growth Factor Receptor-targeted Therapy in Patients with Primary Metastatic Clear Cell Renal Cell Carcinoma: A Pooled Analysis of Prospective Trial Data. Eur Urol Oncol. 2020 Jan 16. pii: S2588-9311(20)30001-8. [Epub ahead of print]
Manara A, Shemie SD, Large S, Healey A, Baker A, Badiwala M, Berman M, Butler AJ, Chaudhury P, Dark J, Forsythe J, Freed DH, Gardiner D, Harvey D, Hornby L1, MacLean J, Messer S, Oniscu GC, Simpson C, Teitelbaum J, Torrance S, Wilson LC, Watson CJE. Maintaining the permanence principle for death during in situ normothermic regional perfusion for donation after circulatory death organ recovery: A United Kingdom and Canada proposal. Am J Transplant. 2020 Jan 10. [Epub ahead of print]
Bryant RJ, Oxley J, Young GJ, Lane JA, Metcalfe C, Davis M, Turner EL, Martin RM, Goepel JR, Varma M, Griffiths DF, Grigor K, Mayer N, Warren AY, Bhattarai S, Dormer J, Mason M, Staffurth J, Walsh E, Rosario DJ, F Catto JW, Neal DE, Donovan L, Hamdy FC; ProtecT Study Group, Bollina P, Doble A, Doherty A, Gillatt D, Gnanapragasam V, Hughes O, Kockelbergh R, Kynaston H, Paul A, Paez E, Rowe E. The ProtecT trial: analysis of the patient cohort, baseline risk stratification and disease progression. BJU Int. 2020 Jan 3.
Books and Chapters
Iyer K and Khan WS. (eds) (2020) Orthopedics of the Upper and Lower Limb. Springer, Cham.
Davies BM and Khan WS (2020) Stem Cell Therapy in Orthopedics. In: Iyer K., Khan W. (eds) Orthopedics of the Upper and Lower Limb. Springer, Cham. pp 565-572
