Kourosh Saeb-Parsy has a long-standing collaboration with Dr Mike Murphy from the Cambridge MRC Mitochondrial Unit to investigate the mechanisms of ischaemia-reperfusion injury (IRI) in organ transplantation and to develop therapeutic approaches for its amelioration. His research utilizes a number of murine, porcine and human models of IRI in collaboration with Prof Mike Nicholson from the University of Cambridge and includes the use of deceased human organs retrieved but declined for transplantation.

He is one of the Investigators in the Mitochondrial Therapies Group  which is focused on developing mitochondria-targeted strategies to minimize IRI in transplantation, myocardial infarction and stroke.

He co-founded and coordinates the annual UK Ex Vivo Normothermic Perfusion Symposium  which aims to share expertise and encourage collaborations focused on the use of ex vivo organ perfusion in transplantation.