Successful liver transplantation is limited by the availability of donor organs and by the inability to assess the viability of ‘marginal’ livers before implantation. In a programme of research led by Professor Watson, we use normothermic machine perfusion, a technique whereby a blood based oxygenated circulation is restored to the liver using extra corporeal membrane oxygenator technology, to determine the suitability of a liver for transplantation. Our research aims to provide further insights into ischaemia-reperfusion injury in the liver, to establish the parameters during machine perfusion that predict optimal liver function after transplantation, and to identify novel therapeutic targets to enable optimal recovery of the liver from ischaemic injury.